Early Blood Test can predict Renal Disease – 5 years before
A new study was published in November 2015 by the New England Journal of Medicine. A new disease marker was found to predict a possible renal disease many years ahead. The circulation protein suPAR, or soluble urokinase-type plasminogen activator receptor, can be messured with a simple blood test.
Chronic Kidney Disease can now be predicated as early as 5 years ahead before the first signs of the damage occurs. Most people are unaware of their condition until it is too late and damage has been done to the organs.
Patients, that have been diagnosed with Chronic Kidney Disease (CKD), are montiopred by two markers in their regular blood tests. Creatinine levels in the blood and protein levels in the urine can be used to monitor the disease and the progression of the condition. However important those messurements are once the patient is aware of his disease, they are not senitive enough to show the decline earlier.
Research on 2,292 participants
The Research was conducted on 2,292 participants. The study was operated between in 2003 and 2009. The participants were to 60 % male and about 63 years of age.
Through a simple blood test their suPAR levels and their creatinine levels were messured. Around 40 % of the participants had high levels of the molecule suPAR, but regular creatinine levels. Still, those individuals developed Chronic Kidney Disease in the following 5 years. Only about 10 % of participants that had low levels of suPAR developed renal failure.
This makes the suPAR molecule a sure telling messurement in predicting renal disease.
The scientists grouped the aprticipants in four categories of suPAR messurements. After 5 years around 15 % of the lower groups were diagnosed with CKD. Scientists found that in the other two groups with higher levels of suPAR 40 % of participants suffered from renal disease.
That so many of the people that took part in the study were diagnosed with a Kidney problem is related due to their age and the fact that they were all already treated for cardiovascular disease.
To make sure that the test results were reliable the scientists conducted another research, the womand interagency HIV study, with 347 HIV positive patients. The results were in agreement. Patients with higher levels of suPAR suffered from renal disease in the following 5 years.
Decomposition until now late measurable
Among the challenges for Nephrologists are reliable values for a continuing reduction before damage was done. Once the renal disease took place it is hard to reverse the progression.
suPAR the possible solution
Compared to the common risk factors, such as High Blood Pressure, suPAR was strongly connected to the decline in Kidney function, says Jochen Reiser from the Rush university Medical Center in Chicago.
Reiser and his collegues discovered a few years ago, that about 2/3 of patients with focal segmental glomerulosclerosis (FSGS) had an increased suPAR messurement.
Through this the idea was born to test if suPAr can also indicate other kidney related problems. Reiser explains that suPAR might also be somehow related to the common diabetic nephropathie.
Prevention of Renal Disease
The fact that renal disease can be predicated far earlier than before opens up higher possibilities for treatment. This allows patients to prevent the decline by weight loss, a healthy diet and to maintain a healthy blood pressure. In NEJM the team of Salim Hayek and Sanja Server states: Through a early prevention the risk to suffer from CKD can be declined by about 50 %.
Ideas on testing possible Kidney donors to see whether they are at risk of developing Cronical Kidney Disease would increase chances of postitive transplant outcomes.
“suPAR finally allows us to glimpse in the future of the kidney”, says Reiser.